Could Blocking IL-17A and IL-17F Increase Infection Risk?

This research looked at how two immune proteins, IL-17A and IL-17F, affect the body’s ability to fight fungal infections like candida. We found that blocking both proteins, a treatment approach used in some inflammatory conditions like psoriatic arthritis, may reduce the movement of protective white blood cells (neutrophils), making it harder to clear infections. Our findings suggest that people receiving medications that block both IL-17A and IL-17F might have a higher risk of fungal infections. This research highlights the importance of monitoring for infections in patients receiving these therapies.