Psoriasis is a chronic skin disease caused by overactive immune responses, particularly involving a pathway driven by IL23, a protein that helps activate inflammation-causing immune cells. We developed a co-culture model using mouse skin and immune cells to study how IL23 triggers inflammation. This system reliably produced key psoriasis-related signals, such as IL17, and allowed us to observe how different treatments might reduce this inflammation. Our model mimics key aspects of the disease without requiring live animal testing, making it a valuable tool for more focused studies to better understand psoriasis and support the development of new therapies.